Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.

Ventricular fibrillation (VF) is an important cause of sudden cardiac arrest following myocardial infarction. Following resuscitation from VF, decreased cardiac contractile function is a common problem. During and following myocardial ischemia, decreased glucose oxidation, increased anaerobic glycolysis for cardiac energy production are harmful and energetically expensive. The objective of the ...

متن کامل

Feeding the Fibrillating Heart: Dichloroacetate Improves Cardiac Contractile

Feeding the Fibrillating Heart: Dichloroacetate Improves Cardiac Contractile 1 Dysfunction following VF 2 Running Title: DCA Treatment for VF Arrest 3 4 Mohammed Ali Azam, Cory S. Wagg, Stéphane Massé, Talha Farid, 5 Patrick F.H. Lai, Marjan Kusha, John Asta, Rafael Jaimes III, Sarah Kuzmiak-Glancy, 6 Matthew W. Kay, Gary D. Lopaschuk, Kumaraswamy Nanthakumar. 7 The Hull Family Cardiac Fibrilla...

متن کامل

The myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure.

Impaired myocardial contractile function is a hallmark of heart failure (HF), which may present under resting conditions and/or during physiological stress. Previous studies have reported that high fat feeding in mild to moderate HF/left ventricular (LV) dysfunction is associated with improved contractile function at baseline. The goal of this study was to determine whether myocardial function ...

متن کامل

Mechanisms underlying hypothermia-induced cardiac contractile dysfunction.

Rewarming patients after profound hypothermia may result in acute heart failure and high mortality (50-80%). However, the underlying pathophysiological mechanisms are largely unknown. We characterized cardiac contractile function in the temperature range of 15-30 degrees C by measuring the intracellular Ca(2+) concentration ([Ca(2+)](i)) and twitch force in intact left ventricular rat papillary...

متن کامل

Myocardial contractile response to physiological stress improves 8 with high saturated fat feeding in heart failure

40 Impaired myocardial contractile function is a hallmark of heart failure (HF) which may 41 present under resting conditions and/or during physiological stress. Previous studies reported 42 that high fat feeding in mild-moderate heart failure/LV dysfunction is associated with improved 43 contractile function at baseline. The goal of this study was to determine whether myocardial 44 function is...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology

سال: 2015

ISSN: 0363-6135,1522-1539

DOI: 10.1152/ajpheart.00404.2015